FDA approves new targeted breast cancer drug


WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.


The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.


Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.


"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."


Cobleigh helped conduct the key studies of the drug at the Chicago facility.


The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.


The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.


Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.


FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.


Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.


FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer


Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.


Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.


Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.


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Eric Garcetti's role in L.A. budget fixes is in dispute









Pressed in the race for mayor of Los Angeles to say how he would fix a persistent budget gap that has led to the gutting of many city services, Eric Garcetti urges voters to look at what he has done in the past.


The onetime City Council president claims credit for reforms that he said cut the City Hall shortfall to just over $200 million from more than $1 billion. He sees "tremendous progress," principally in reducing pension and healthcare costs, and asserts: "I delivered that."


But the truth is in dispute. Although there is not a singular view about any aspect of the city's troubled finances, most of those in the thick of recent budget fights depict Garcetti not as a fiscal hard-liner but as a conciliator who used his leadership position to chart a middle ground on the most significant changes.





Mayor Antonio Villaraigosa, city administrative officer Miguel Santana and one of Garcetti's rivals in the mayoral race, Councilwoman Jan Perry, were among those who pushed for bigger workforce reductions and larger employee contributions toward pensions and healthcare. Labor leaders and their champions on the City Council, including Paul Koretz and Richard Alarcon, sought to cushion the blow for workers.


Garcetti and his supporters say he moderated between those extremes. His critics said he worried too much about process and airing every viewpoint rather than focusing relentlessly on shoring up the city's bottom line.


"It was through the mayor's persistence and steadfast position that we got ongoing concessions," said Santana, the chief budget official for Los Angeles. "It was in collaboration with the council leadership that we finally reached agreements with labor."


The $1-billion-plus deficit Garcetti speaks of shrinking refers not to a single year but to the total of budget gaps that confronted Los Angeles over four years if no corrective action had been taken. The city's fiscal crisis worsened during that time because Garcetti and his fellow council members — including Perry and mayoral candidate Wendy Greuel — approved a city employee pay raise of 25% over five years just before the country stumbled into the recession. (Greuel left the council in 2009 when she was elected city controller.)


Although Garcetti focuses on his role, a portion of the financial improvements were outside his control. The state's elimination of redevelopment agencies in 2012 returned millions to L.A.'s general fund. Tax revenue also ticked upward with the economic recovery.


Garcetti's position as council president from 2006 through 2011 did put him at the center of debate about annual shortfalls that ranged to more than $400 million.


In 2009, he supported an early retirement plan that knocked 2,400 workers off the payroll. "I really pushed that through," the councilman said in an interview. Two participants in confidential contract talks at the heart of the deal had diametrically opposed views. "He made it happen, period," one said; the other offered: "I wouldn't say he was a major mover."


The plan saves the city a maximum of $230 million a year in salary and pension reductions in the short run. But Los Angeles borrowed to spread the costs of the program over 15 years, with current employees and retirees expected to shoulder the cost of the early exits.


The early retirements are expected to do nothing to resolve the long-term "structural deficit" — the $200 million to $400 million a year that Los Angeles spends above what it takes in. And early retirements could even be a net negative in the long run if, as city revenue recovers, new employees are put in those 2,400 empty positions too quickly.


In 2010 the city completed a budget fix that did attack the structural imbalance.


Garcetti's initial proposal called for upping the retirement age for new city employees to 60 from 55 and requiring workers to contribute a minimum of 2% of salary toward their retiree health care.


Budget chief Santana offered a markedly tougher plan. It required a 4% retiree health contribution, halved the health subsidy for retirees and capped pension benefits at 75% of salary instead of 100%. Santana's plan, also for new employees, became the basis of the reform.


Some who served with Garcetti on the council committee that leads employee negotiations pushed for even greater sacrifices. But Garcetti fought against ratcheting up demands on workers, saying it would be useless to approve a plan that would not survive subsequent union votes.


The councilman's greatest contribution may have come after city leaders set their position on pensions. Garcetti took the unusual step of visiting groups of workers. Some employees booed. Some asked him why city lawmakers, among the highest paid in the nation at $178,000 a year, didn't cut their own salaries.


"There was a lot of anger," said a labor leader who spoke on condition of anonymity because that union has not endorsed in the race. "But Eric talked to people as if they were adults and stayed until he answered all their questions. People appreciated him ... taking that kind of heat."


Matt Szabo, a former deputy mayor who helped negotiate with labor, said Garcetti deserved "every bit of credit" he has claimed for deficit reduction. "He knew he was running for mayor, and he was doing the right thing, but it was something that was going to cost him later" in terms of union support, said Szabo, who is running to replace Garcetti on the council.


Most of the employee groups that have endorsed thus far in the mayor's race have come out for Greuel. One political advantage for the controller: She left the council in 2009, before the city began making its toughest demands on workers.


Garcetti found himself stuck the middle again with another 2010 vote, this one over the elimination of 232 jobs — most of them in libraries and day care operations at city parks. Garcetti voted for the layoffs. Later he voted to reconsider, though he said recently that he intended only to re-air the issue, not to keep the workers on the job.


Labor leaders faulted Garcetti for giving the appearance he might be ready to save the jobs when he really wasn't. The reductions remain a sore point, because a "poison pill" in the contract required that any layoffs be accompanied by immediate pay raises for remaining city employees. Fierce disagreement remains over whether the layoffs saved the city any money.


"That became part of the negative picture" of Garcetti, said one labor leader, who asked not to be named out of concern about alienating a possible future mayor. The candidate said in an interview that he frequently found himself hewing a middle ground between some colleagues "who simply hope more revenue would come in" and others who wanted to use an "ax," making indiscriminate cuts. He added: "To me, both views were equally unacceptable."


Critics find Garcetti too malleable, ready to shift to the last argument he has heard. But others appreciate his quest for the middle, saying the fact he sometimes irritated both budget hard-liners and unions showed he had taken a reasoned approach.


"The criticism of Eric is also sort of the good news," said one of the union reps. "He has this very process-y, kumbaya, can't-we-all-get-along style. It drove us all crazy. But now I really miss it because it seems to be all politics over policy."


james.rainey@latimes.com





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3 Convicted in Britain Over Terrorist Plot





LONDON — Three men accused of plotting what prosecutors said would have been the most devastating terrorist attacks in Britain since the London transit system bombings of July 2005 were convicted Thursday after a 12-week trial. The judge hearing the case told the men to expect sentences of life imprisonment.




Prosecutors said the three men — Irfan Naseer, 31, Irfan Khalid, 27, and Ashik Ali, 27, all British citizens from the industrial city of Birmingham in the English Midlands — planned to detonate up to eight homemade bombs in rucksacks in crowded places, the method used by the four suicide bombers who killed 52 other people on London subway trains and buses in 2005.


That attack prompted MI5, the domestic security service, and police forces across the country to rapidly expand their counterterrorism efforts. Officials at MI5 and at Scotland Yard have said that the authorities track dozens of active terrorist cells, and they cite a series of successful prosecutions and the absence of any attack that led to mass casualties in Britain since the transit bombings as evidence of their success.


The court in Birmingham was told that the authorities had the three defendants under close surveillance from an early stage, along with nine co-conspirators, six of whom have pleaded guilty to terrorism charges. The police officer who led the surveillance, Detective Inspector Adam Gough, described the three men, all Muslims, as “committed, passionate extremists,” and added, “They had a real stated intention to kill and maim as many people as they possibly can.”


The men were still discussing potential targets and weapons when they were arrested in September 2011 as they drove across Birmingham, prosecutors said. From bugged conversations and police questioning, the court heard, the men were known to have discussed using rucksack bombs, rifle attacks on crowded streets and targeted strikes against British soldiers; more arcane methods were also mentioned, including putting poison on the car-door handles of intended victims and fitting long blades to the hoods and wheels of cars to be driven onto crowded sidewalks to scythe people down.


Mr. Naseer, said to be the ringleader, was described at the trial as a “fantasist” who had been teased and nicknamed Chubby at school for being overweight and who resolved as he grew into adulthood, gaining a pharmacy degree, to make a name for himself as a violent jihadist. He and his associates spoke frequently of their hatred for Britain, particularly after British troops occupied Afghanistan and Iraq, the prosecution said.


Two of the men, Mr. Naseer and Mr. Khalid, were tracked by the security services leaving Britain and entering terrorist training camps linked to Al Qaeda on the Pakistan-Afghanistan border. Later, the prosecution said, the two arranged for four other young Birmingham men to travel to Pakistan for terrorist training. Those four were among the six who pleaded guilty at an earlier trial.


The prosecution said that the three main Birmingham plotters were overheard criticizing the 2005 transit attackers for failing to include loose nails in their bombs to make them more lethal. The court heard that Mr. Naseer and his fellow plotters were heavily influenced by the extremist propaganda of Anwar al-Awlaki, the American-born cleric who was killed by an American drone strike in Yemen in September 2011. They learned of Mr. Awlaki’s teachings from an English-language magazine, Inspire, that was founded by Mr. Awlaki and distributed over the Internet, the prosecution said; it claimed that it was from the magazine that they took the idea of attaching blades to the wheels of cars and creating what the magazine called “the ultimate mowing machine.”


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PHOTO: Seth MacFarlane Lets Popcorn Fly in New Oscar Promo















02/21/2013 at 04:45 PM EST



Seth MacFarlane isn't crying over spilled popcorn.

Before he gets down to the business of hosting on Sunday's 85th Annual Academy Awards, MacFarlane 39, posed in a lighthearted set of promotional photos, leading up to Hollywood's biggest night.

In one of the shots, the Family Guy creator is holding a tub of popcorn – but in the next, the kernels are flying everywhere, much to the star's delight. In another shot, MacFarlane does his best impression of Oscar himself.

MacFarlane will make his Academy Awards hosting debut live on ABC from the Dolby Theatre in Hollywood.

Previously, MacFarlane shot a silly video promo pretending to be Daniel Day-Lewis.  

PHOTO: Seth MacFarlane Lets Popcorn Fly in New Oscar Promo| Academy Awards, Oscars 2013, TV News, Seth MacFarlane

Seth MacFarlane

BOB D'AMICO / ABC

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Doctor sexually assaulted unconscious patients, police say



Yashwant Balgiri GiriAn Orange County anesthesiologist convicted of sexually assaulting three unconscious female patients  has been sentenced to six months in jail and five years probation, despite the objections of prosecutors who wanted state prison time.


Yashwant Balgiri Giri, 60, pleaded guilty to a court offer to multiple felony counts related to the sexual battery of patients, including a 16-year-old, according to a statement from the Orange County district attorney's office.


Giri will have to register as a lifetime sex offender and will have his medical license revoked, in addition to the jail time and probation.


Prosecutors sought a state prison sentence, citing a violation of his "position of power and trust" with the women at a particularly vulnerable time.


Giri, who lives in Cypress, was working at Placentia-Linda Hospital at the time of the crimes, prosecutors said. He previously worked at several hospitals in Anaheim and Lakewood.


Through a spokeswoman, Placentia-Linda Hospital declined to comment.


Prosecutors said that in February 2009,  while a 16-year-old was unconscious from medication, Giri assaulted the girl when a scrub nurse preparing surgery tools had her back turned. The nurse witnessed the assault, prosecutors said, and reported it immediately to a hospital official.


Prosecutors allege that the hospital did not report the incident to police at the time.


In March 2011, prosecutors said, a hospital employee witnessed Giri fondling the breasts of a 36-year-old woman while she was under anesthesia for an outpatient surgery procedure.


An employee allegedly witnessed the incident  Prosecutors said the fondling continued for an extended period of time, as his actions were concealed from the surgeon and nurse.






The alleged assault was reported to a hospital official and then to Placentia police, prosecutors said.

Soon after an investigation began, Giri resigned from his duties at the hospital.


After he was arrested in May 2011, a third alleged victim stepped forward, saying she had been assaulted by Giri.


In April 2010, prosecutors said, Giri assaulted a 27-year-old woman while she was being put under anesthesia but before she was unconscious. Prosecutors said he touched the woman under the pretense of performing an examination, although it had no legitimate medical purpose.


During a sentencing hearing, a statement from the then-36-year-old woman, who was fondled, was read by prosecutors.


"His actions make me question every single doctor, nurse, medical decision and procedure I encounter within my everyday life," she said. "I not only fear for myself, I fear for my child, my friends, my family. This is a burden caused by the perverted actions of this predator."


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-- Rick Rojas


Photo: Yashwant Balgiri Giri. Credit: Orange County district attorney's office.


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IHT Special: Lebanon Voting Plan Stirs Sectarian Fervor







BEIRUT — A controversial draft law to overhaul Lebanon’s electoral system gained traction Tuesday when a parliamentary joint committee supported it, raising the possibility that voters will in future be able to cast ballots only for candidates from their own sect.




Proponents say the law would protect their communities and ensure fairer elections. Opponents say it would further entrench sectarianism in a sharply divided country.


“Election law was one of the last things that wasn’t codified in sectarian terms,” said Emile Hokayem, an analyst with the International Institute for Strategic Studies, or I.I.S.S., in Bahrain.


The change, known as the Orthodox Proposal, was first supported by Christian parties that felt their communities were misrepresented in past elections.


Lebanon’s political system is largely governed by sectarian quotas and criteria. Under an agreement reached at independence in 1943, the president is always a Maronite Christian, the prime minister a Sunni Muslim and the speaker of Parliament a Shiite. Parliamentary seats are split evenly between Christians and Muslims: Each specific sect within these groups — for example Greek Orthodox Christians or Druze Muslims — is allocated a set number of seats.


The number of seats allocated to each group is now quite arbitrary since there has been no census in Lebanon since 1932. Quotas and electoral districts have been adjusted since, but the demographic base for the system remains the 80-year-old, and visibly obsolete, poll.


The system, intended to promote coexistence, has instead become a driving factor in Lebanon’s conflicts over the years, most notably its 15-year civil war.


In past elections, Lebanon was divided into electoral districts — 26 in 2009, up from 14 in the previous two elections, in 2000 and 2005. In each district, seats were allocated on a sectarian basis, but voters could cast ballots for any candidate, with one vote for every available seat, regardless of sect.


Christian parties have argued that the system allowed many seats reserved for their communities to be decided by Muslim votes.


In Lebanon’s second-largest city, Tripoli, for example, two parliamentary seats are reserved for Christian sects, but the overwhelming majority of residents are Sunni Muslims. Even if every Christian in the city voted en bloc for two candidates, the outcome could still be determined by Sunni voters.


In other districts, seats are only allocated to one sect despite the presence of other groups.


“There is a really deep feeling within the Christian community today in Lebanon that it’s time to stop this injustice,” said Farid El Khazen, a member of Parliament from the Free Patriotic Movement, a Christian party, who supports the draft law.


As well as limiting voters’ choices to candidates from their own sect, the proposal would replace local voting districts with a single, nationwide poll.


The parliamentary committee vote Tuesday showed support for the proposal from Amal and Hezbollah — the principle Shiite factions — as well as the main Christian parties. Among the plan’s harshest critics have been the Sunni-affiliated Future Movement, the Druze-backed Progressive Socialist Party and President Michel Suleiman.


Rhetoric for and against the law has been fervent. Opponents have called it unconstitutional and warned that it would encourage extremism. Saad Hariri, leader of the Future Movement and a former prime minister, took to Twitter to call Tuesday a “black day” for the Lebanese Parliament.


But Michel Aoun, head of the Free Patriotic Movement, said that Tuesday was the happiest day in Lebanon’s history.


Parliamentary elections are slated for June but could be delayed. The proposal needs to go before the entire Parliament, and if passed could be vetoed by the president. The outcome remains unclear.


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Can You Guess Which Star Was First To Wear Elizabeth Taylor's $6 Million Emerald Necklace?







Style News Now





02/20/2013 at 11:15 AM ET











Julianne Moore Elizabeth TaylorNate Beckett/Splash News Online; Popperfoto/Getty


On Tuesday night, Julianne Moore did what few women would be able to: She did justice to one of Elizabeth Taylor‘s most prized pieces of jewelry.


The dazzling emerald-and-diamond necklace, purchased for Taylor by future husband Richard Burton while they were on location for Cleopatra in Rome, was a staple in the legendary star’s wardrobe; she even wore it to accept her Oscar in 1967.


It was one of eight Bulgari pieces that the jewelry house purchased from her 2011 Christie’s auction and now have on display at their Rodeo Drive flagship.



“The room absolutely stopped when [Moore] entered” in the necklace, a source at Bulgari’s pre-Oscars party, thrown to celebrate Taylor’s jewels, tells PEOPLE. “Kirsten Dunst exclaimed, ‘Are you wearing one of her pieces?’”


And Moore looked lovely in the necklace, which sold for more than $6 million at auction, though she went a distinctly non-Taylor route by offsetting it with sleek hair and a very simple Alexander McQueen dress. Regardless, we bet Taylor, who wore her fanciest jewelry to sit around the house, would have been pleased.

Tell us: What would you wear with Taylor’s $6 million emerald necklace?


–Alex Apatoff, reporting by Jennifer Garcia


PHOTOS: SEE MORE OF ELIZABETH TAYLOR’S JAW DROPPING JEWELRY HERE!




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Obama administration tackles colonoscopy confusion


WASHINGTON (AP) — It's one part of the new health care law that seemed clear: free coverage for preventive care under most insurance plans.


Only it didn't turn out that way.


So on Wednesday, the Obama administration had to straighten out the confusion.


Have you gone for a colonoscopy thinking it was free, only to get a hefty bill because the doctor removed a polyp?


No more.


Taking out such precancerous growths as part of a routine colon cancer screening procedure will now be considered preventive care.


"Polyp removal is an integral part of a colonoscopy," the Department of Health and Human Services said in guidance posted on its website. That conclusion has the backing of several leading medical societies, the department noted.


Also addressed in the notice was genetic testing for breast cancer, coverage of over-the-counter products such as aspirin for heart care and nicotine patches for smoking, and birth control for women. Unlike formal regulations, the guidance does not have the force of law, but advocates for patients say insurers would be ill-advised to ignore it.


President Barack Obama's health care law required most private health plans to cover preventive care at no additional charge to patients. It also expanded preventive coverage without copayments for Medicare recipients. For workers and their families, the expense is borne by the company health plan, which passes on some of those costs in the form of higher premiums. Advocates say preventive care saves the health care system money over time.


Colonoscopy is an expensive test that can cost more than $1,000. It's recommended for adults 50 and over, and has become a rite of passage for aging baby boomers.


News that it would be covered free under the health care law got attention, but that was followed quickly by a letdown when many insurers started charging if a polyp or two was discovered and removed during the procedure.


"Insurers were reclassifying it from a preventive test to a diagnostic procedure," said Stephen Finan, policy director for the American Cancer Society Cancer Action Network. "In some cases the cost-sharing was a significant amount of money."


His group was among several that complained to the administration.


Other free preventive services addressed in Wednesday's guidance:


—Insurers must cover testing, if ordered by a doctor, for rare BRCA genes that dramatically increase the risk of breast cancer. Such tests can cost as much as $3,000.


—Over-the-counter products such as aspirin for heart care and nicotine patches for smoking cessation are covered with a doctor's prescription.


—Insurers won't be able to fulfill the law's requirement to cover contraception as preventive care for women if they only pay for birth control pills. A full range of FDA-approved methods must be covered, including long-acting implant and intrauterine devices. Birth control methods for men are not covered as preventive care.


If a health plan does not have a network doctor who performs a particular preventive service, a patient can see a doctor out-of-network without facing copays or additional charges.


Also Wednesday, the government came out with final rules on the benefits that health plans catering to individuals and small businesses will have to offer starting next year, when new insurance markets called exchanges open in each state.


The coverage generally is better than what's now available to people buying individual policies, but close to what medium-size companies offer, with some important improvements in areas such as mental health care.


Benefits include hospital and outpatient care, emergency services, maternity and newborn care, prescriptions, prevention, rehabilitation and ongoing assistance for people with potentially disabling conditions, and dental and vision care for children.


All plans will have to cover the same benefits, but their premiums and cost sharing will vary. There will be four level of coverage — bronze, silver, gold and platinum. Bronze plans will cover 60 percent of expected costs while platinum plans will cover 90 percent.


___


Online:


Health and Human Services Department: http://tinyurl.com/au6lzeo


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Tourist's body found stuffed in hotel water tank; guest horrified



There were few details Wednesday on how the body of a missing Canadian tourist ended up at the bottom of a water tank on the roof of a downtown hotel.


For days, residents of the Cecil Hotel thought something was amiss. At least one said there was flooding in one of the fourth-floor rooms, while others complained about weak water pressure.
One of those complaints led a hotel maintenance worker to check Tuesday on one of the large metal water cisterns on the roof, where he discovered the body of an unidentified woman in her 20s at the bottom of the tank.



Authorities said late Tuesday the body was that of Elisa Lam, 21, a Vancouver, Canada, woman last seen at the hotel Jan. 31.


"We're not ruling out foul play," said LAPD Sgt. Rudy Lopez, noting that the location of the remains "makes it suspicious."



Los Angeles police investigators searched the roof of the Cecil with the aid of dogs when Lam was reported missing about three weeks ago. Lopez said he didn't know if the tanks were examined.



"We did a very thorough search of the hotel," he said. "But we didn't search every room; we could only do that if we had probable cause" that a crime had been committed.



Once a destination for the rich and famous in the 1930s and '40s, the Cecil has gradually deteriorated, mirroring the decay of downtown Los Angeles, particularly in the skid row area. With rock-bottom rents and flexible stays, the historic 1927 building attracted those who were a step away from homelessness.



The Cecil also became a magnet for criminal activity. Most notably it was the occasional home to infamous serial killers Jack Unterweger and Richard "Night Stalker" Ramirez. Even after a multimillion-dollar makeover in 2008, police said they frequently respond to the Cecil for calls relating to domestic abuse and narcotics.



In 2010, the hotel was the scene of a bizarre incident in which a Los Angeles city firefighter who had been honored as paramedic of the year said he was stabbed while responding to a distress call. But police found inconsistencies in the story and no assailant was ever located.



On Tuesday, the Cecil grappled with a deeper mystery.
According to detectives with the LAPD's Robbery-Homicide Division, Lam came to Los Angeles from Vancouver on Jan. 26. While they did not discuss her exact movements or whether she visited anyone here, they believe her ultimate destination was Santa Cruz. Lam's reasons for visiting California were unclear, detectives said.


She was last seen Jan. 31 inside the elevator of the hotel. In surveillance footage, Lam is seen pushing buttons for multiple floors and at one point stepping out of the elevator, waving her arms.
A cause of death is still to be determined by county coroner’s officials, Lopez said.


A locked door that only employees have access to and a fire escape are the only ways to get to the roof. The door is equipped with an alarm system that notifies  hotel personnel if someone is up there, Lopez said.


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O.C. shootings: Killings occurred during morning routines


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Woman who ran surrogate parenting firm pleads guilty in fraud case


— Andrew Blankstein and Adolfo Flores



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At War Blog: General Allen's Tenure in Afghanistan

Most Americans probably know of him only as a secondary character in the sweeping drama of David H. Petraeus’s affair with his biographer, Paula Broadwell. But Gen. John R. Allen, who announced Tuesday that he would retire from the Marine Corps rather than become the top commander of NATO, was for more than a year and a half the commander of NATO forces in Afghanistan. And when he said farewell to the job recently, he made clear that he wanted to be remembered for more than his bit role in that scandal.

After receiving a medal for his service, just before turning over his command to a fellow Marine, Gen. Joseph Dunford, General Allen surprised some in the audience by declaring unequivocally: “This campaign is successful. We are winning. We are winning.”

During a news conference with a small group of reporters later, General Allen expanded on his confident description of the war – one, polls suggest, that is not shared by many Americans.

“There is no, in the Napoleonic sense, there is no decisive battle,” he said. But he said he saw daily evidence that the Afghan National Security Forces, or A.N.S.F., were getting better. “I see it contributing to the end state, which ultimately is the A.N.S.F. moving into the lead and creating space ultimately for the government of Afghanistan to get up on its feet,” he said.

“We’re not done,” he added. “But I’m comfortable that the trajectory is moving us in the direction we ultimately want to go.”

Asked if widespread corruption by the Afghan government had irreparably undermined its credibility with the people and pushed them toward the Taliban, General Allen acknowledged concerns.

“I think we all have to recognize the limits of the capacity of the Afghan people and the government at this particular moment,” he said. “We’re coming out of 33 years of conflict. Coming out of an environment where the school system was largely decimated or devastated, whichever D-word you want to apply to it.”

The key to the government’s continued stability – and to an international willingness to continue providing it aid – will be its ability to hold a safe and credible presidential election in 2014, General Allen said.

“We’ve reached the point where the rhetoric, while it was encouraging, isn’t enough anymore,” he said. “The rhetoric has to be accompanied by action. The rhetoric has to be accompanied by real and meaningful reform. Reform that reduces the capacity of the criminal patronage networks to grip and weaken institutions of state. Reform that genuinely takes care of the rights of minorities, and particularly the rights of women.”

During his tenure, General Allen had more than his share of crises: a video of Marines urinating on Taliban corpses; the burning of Korans by American soldiers; civilian deaths in allied airstrikes; the massacre of 16 civilians, in which an American soldier has been charged; and a spate of insider attacks by Afghan forces on NATO troops.

He also had to work hard to repair frayed relationships with President Hamid Karzai, who clashed openly with Mr. Petraeus, General Allen’s predecessor as head of international forces in Afghanistan. As The Times’s Matthew Rosenberg noted in a recent article, General Allen established an amicable enough relationship that Mr. Karzai called him to offer condolences while the general was on home leave in Virginia last year for his mother’s funeral.

As Mr. Rosenberg tells it, General Allen had not told anyone in the Afghan government before flying home to bury her. Then, while eating with his family in the Shenandoah Valley, he got a phone call from President Karzai.

“So I’m in the parking lot, it’s just surreal,” General Allen said. “Talking to the president of Afghanistan, who is gripped with emotion saying words to the effect that our mothers are so precious to us.”

A transcript of the interview that accompanied that article, in which General Allen described how he dealt with the Koran burnings, the Panjwai massacre and other crises, can be found here.

As if juggling all that were not enough, General Allen’s reputation came under a cloud when e-mails between him and a socialite in Tampa, Fla., Jill Kelley, emerged during the investigation of General Petraeus’s affair with Ms. Broadwell. After a lengthy review of those e-mails, the Defense Department’s inspector general cleared General Allen of any wrongdoing. The decision allowed President Obama’s nomination of General Allen to become the top NATO commander and head of the United States European Command to proceed.

But during his farewell at his headquarters in Kabul on Feb. 10, General Allen sent what might have been a signal about his plans to retire. He closed his remarks with generous praise of his wife, noting that many generations of her family had served in the military and that she had patiently endured 29 moves with him during 35 years of marriage. General Allen told The Washington Post that he was retiring to help his wife, Kathy, cope with chronic health problems.


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